Cancer Immunology & Immunotherapy Laboratory

The crucial role of immunology in cancer research, as well as the advances in the understanding of tumor immunobiology highlight the need to focus on cancer immunology and Immunotherapy at
Shiraz Institute for Cancer Research (ICR). Cancer Immunology research projects were the main line of investigations once ICR was established in 1998. The work group was then extended and physically centralized in an independent laboratory in January 2006 following extension of the physical space of the institute.
Cancer Immunology & Immunotherapy research group investigates the molecular and cellular aspects of immune system in cancer patients. Equipped with cell culture facilities as well as cell- and molecular-analyzers (including Flow cytometer and DNA sequencer), the research group is currently targeted both basic and clinical aspects of the cells and molecules involved in cancer immunity. In collaboration with
Stem Cells Biology research groups in ICR, as well as the Institute for Regenerative Medicine, the group also aims to translate the knowledge of basic immunology into clinical setting.


The main goals of the projects undertaken are:

Ø  Immune cell therapy in cancer patients: Autologous NK cell therapy trial in collaboration with a Japanese university hospital is in progress

Ø  Regulatory T and helper T cells as well as memory response in cancer, new concepts and therapeutic applications

Ø  Investigation of the immune response inhibitory state in patients with cancers

Ø  Assessment of In vitro anti-tumoral activity as well as immune effects of anticancer loaded nano/micro-particles and newly designed therapeutic agents

Ø  Molecular analysis of the immune-related genes in patients with cancers


Cancer immunology & Immunotherapy laboratory is currently directed by Nasrollah Erfani, PhD in collaboration with Zahra Faghih, PhD.

Follow the link to see the list of the institute staff.

Shiraz University of Medical Sciences
Shiraz Institute for Cancer Research (ICR)
P.O. Box: 71345-3119
Tel: +98(0)71 32303687
Fax: +98(0)71 32304952